Xct Glioma

Expression Of C-Terminal Modified Serine Palmitoyltransferase ...
Glioma cells in culture are known to release relatively high levels of also referred to as xCT, a heterodimeric antiporter subunit member of the Expression of C-Terminal Modified Serine Palmitoyltransferase-1 Alters Chemosensitivity of Inflammation-Associated Human Cancer Cell ... Fetch Doc

xCT Modulation In gliomas: Relevance To Energy Metabolism And ...
XCT modulation in gliomas: Glioma cells release excitotoxic concentrations of glutamate. Cancer Res. 59 (17), 4383–4391. Title: xCT modulation in gliomas: Relevance to energy metabolism and tumor microenvironment normalization Author: Nic E. Savaskan ... Read More

Overexpression Of xCT Induces Up-regulation Of 14-3-3β In ...
Overexpression of xCT induces up-regulation of 14-3-3β in Kaposi’s sarcoma Yan ZENG*†, in multiple cancers such as hepatoma, lymphoma, glioma and lung, colon, breast, prostate and pancreatic cancer cells, which renders xCT a potential drug target for cancer therapy [13]. ... Return Document

NeurobiologyofDisease ...
NeurobiologyofDisease InhibitionofCystineUptakeDisruptstheGrowthofPrimary BrainTumors Importantly, prominent expression of xCT was also found in biopsies from glioma patients and in biopsies obtainedfromnonmalignantbraintissue(Fig.1b).Thesestudies ... Retrieve Full Source

SAN TA C RUZ BI OTEC HNOL OG Y, INC . xCT (H-121): Sc-98552
SAN TA C RUZ BI OTEC HNOL OG Y, INC . xCT (H-121): sc-98552 xCT is associated with the pathogenesis of glioma-induced neurodegeneration and brain edema, xCT (H-121) is a rabbit polyclonal antibody raised against amino acids ... Document Viewer

SANTA CRUZ BIOTECHNOLOGY, INC. xCT (N-19): Sc-79359
XCT (N-19): sc-79359 in amino acid transport, xCT is associated with the pathogenesis of glioma-induced neurodegeneration and brain edema, as well as pancreatic cancer. The gene encoding xCT maps to human chromosome 4, which encodes nearly ... Get Doc

xCT, Component Of Cysteine/glutamate Transporter, As An ...
XCT, component of cysteine/glutamate transporter, as an independent prognostic factor in human esophageal [13] showed that xCT affects glioma invasion through the autocrine glutamate signaling loop in the brain. Ishimoto et al. [11] showed that CD44 ... Visit Document

Glutamate Release By Primary Brain Tumors Induces Epileptic ...
Gliomas are the deadliest and most common of primary brain tumors, and they currently lack effective treatments. (xCT) and a regulatory (CD98) subunit, both of which are highly Glioma-bearing mice show recurrent epileptic activity. ... Read Content

Www.nature.com
Supplementary Information. Title of manuscript: Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration ... Read Here

Systemxc AndThioredoxinReductase1Cooperatively ...
AndThioredoxinReductase1Cooperatively RescueGlutathioneDeficiency* that forced expression of xCT, the substrate-specific subunit of thecystine/glutamateantiporter,in GSHandglutathioneperoxidase4andtranslatedintoadistinc--glutamylcysteinesynthe- ... Read Here

HYPOXIA INCREASES THE DEPENDENCE OF GLIOMA CELLS ON ...
GLIOMA CELLS ON GLUTATHIONE Toyin Adeyemi Ogunrinu and Harald Sontheimer From the Department of Neurobiology & Center for Glial Biology in Medicine, expression of xCT, the catalytic subunit of system xc-and L-cystine uptake. Growth is ... Fetch Here

SLC7A11 Expression Is Associated With Seizures And Predicts ...
Glioma is the most common malignant primary brain tumo r. Its rapid growth is aided by tumor-mediated gluta- Probing expression of SLC7A11/xCT, the catalytic subunit of SXC, in patient and mouse-propagated tissues, we found that ~50% of patient tumors have elevated ... Fetch This Document

SAN TA C RUZ BI OTEC HNOL OG Y, INC . xCT (Q-18): Sc-79360
SAN TA C RUZ BI OTEC HNOL OG Y, INC . xCT (Q-18): xCT is associated with the pathogenesis of glioma-induced neurodegeneration and brain edema, as well as pancreatic cancer. The gene encoding xCT maps to human chromosome 4, which encodes nearly ... Retrieve Content

AutocrineGlutamateSignalingPromotesGliomaCellInvasion
Consistingofacatalyticlightchain(xCT),whichconfersspecificity, and a regulatory heavy chain (4F2hc), which localizes the from the same or neighboring glioma cells drives the process making it an autocrine or paracrine signal, thus increasing the abilityofthegliomacelltoinvade. ... Read Document

Glutamate Release By Primary Brain Tumors Induces Epileptic ...
(xCT) and a regulatory (CD98) subunit, glioma-bearing mice to permit both in vivo and in situ analysis. Glutamate release by primary brain tumors induces epileptic activity Susan C Buckingham, Susan L Campbell, Brian R Haas, ... Retrieve Document

Oxidative Stress And Glutamate Release In Glioma - InTech
Oxidative Stress and Glutamate Release in Glioma Robert Ungard and Gurmit Singh McMaster University The myriad consequences originating from the upregulation of xCT in glioma have uncovered several novel possibilities for treatm ent of glioma. ... Access Doc

Cerebral Cystine Uptake:a Tale Of Two Transporters
Overexpression of xCT alone in HEKcells increases cystine–glutamate exchange [6] but the human xCT glioma cells express two variants of the light chain hxCT subunit, hxCTa and hxCTb, that differ in their C-terminal regions and might be formed by alternative splicing. Both variants exist in ... Get Doc

ROLE OF THE CYSTINE/GLUTAMATE EXCHANGER IN GLIOMA CELL ...
ROLE OF THE CYSTINE/GLUTAMATE EXCHANGER . IN GLIOMA CELL BIOLOGY . TOYIN ADEYEMI OGUNRINU . DEPARTMENT OF NEUROBIOLOGY . xCT expression in each glioma sample was evaluated to determine if it fell at, below or above the mean baseline xCT expression. ... Doc Retrieval

Fenretinide - Wikipedia, The Free Encyclopedia
Fenretinide accumulates preferentially in fatty tissue such as the breast, prostate, cervical, lung, renal, bladder, breast, glioma, skin, head and neck carcinoma, non-Hodgkin's lymphoma, neuroblastoma, XCT-790; ERR β. Agonists: DY-131; GSK ... Read Article

HypoxiaIncreasestheDependenceofGliomaCellson Glutathione S
HypoxiaIncreasestheDependenceofGliomaCellson subunit,4F2hc/CD98,andacatalyticlightsubunit,xCT,which confers the specificity of this transport system. During glioma expansion, oxygen becomes limiting due to poor tumor vasculature (9, 10). ... Get Document

Histone Deacetylases Inhibition By SAHA/Vorinostat Normalizes ...
Histone deacetylases inhibition by SAHA/Vorinostat normalizes the glioma microenvironment via xCT equilibration Ines M. L. Wolf1*, Zheng Fan 1*, Manfred Rauh2, Sebastian Seufert3, Nirjhar Hore , Michael Buchfelder1, ... Read More